Tideglusib is an irreversible GSK-3 inhibitor with IC50 of 5 nM and 60 nM for GSK-3βWT and GSK-3βc199A, respectively Invitro Tideglusib (NP12), a small heterocyclic thiadiazolidinone (TDZD) derivative, is a noncompetitive inhibitor of GSK-3β with IC50 values in the micromolar range. Incubation of astrocyte and microglial cell cultures with Tideglusib (NP031112) completely abolished the induction of TNF-α and COX-2 expression after glutamate treatment. These effects of NP031112 were not caused by loss of cell viability, as 24 h exposure of astrocytes and microglia to this TDZD did not alter cell viability.
Function
Tideglusib is a potent, selective and irreversible small molecule non-ATP-competitive GSK3 inhibitor that has been investigated as a potential treatment for Alzheimer's disease and paralysis supranuclear palsy in Phase IIa and IIb clinical trials.
Related products:API family has a very large family like Peptides Products and Plant Extract products. Therefore, our factory is very strong in research and development here, hoping to serve more families and enterprises. Besides the three of them, we have also made important breakthroughs in peptide and polypeptide.Besides Peptide Powder, raw pharmaceutical powder, puzzle powder and plant extract are also popular products.
Why choose us？
1.OEM/ODM Available.
2. Raw materials from chinese origin
3. Best quality in your requirement
4. Competitive price in china market
5 Fast delivery and free sample for your evaluation.Stock availability
6.Door to door shipping service is available.
7. Professional documents for your custom clearance.
8. Full experience of large numberscontainers loading in chinese sea port
9. Packing with pallet or as buyer's special request
10. Best after-service after
About us
Company Profile:Our company offers variety of products which can meet your multifarious demands.including API Powder 、Pharmaceutical Intermediates、Vitamins Powder、Plant Extracts、Food Additive、Peptide Powder and so on We adhere to the management principles of "quality first, customer first and credit-based" since the establishment of the company and always do our best to satisfy potential needs of our customers. Our company is sincerely willing to cooperate with enterprises from all over the world in order to realize a win-win situation since the trend of economic globalization has developed with anirresistible force.
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FAQ
Q1: Are you a manufacturer?
Answer: Yes
Q2: How to contact with us?
Click the Google "Contact Supplier" And then send us message the product you interest in, you will get reply within 24 hours.
Q3:Which kind of payment terms do you accept?
For small order,you can pay by T/T,Western Union or online ,nomal order by T/T to our company account
Q4:Can you give me a discount price?
Surely,It depend on your qty
Q5:How can i get a sample?
free samples is available,but freight charges will be at your account and the charges will be return to you or deduct from your order in the future.
Q6: How to confirm the Product Quality before placing orders?
A:You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.
Q7:How do you treat quality complaint?
A:First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us,
we will send you free goods for replacement or refund your loss.
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