PT-141 (Bremelanotide) originally developed from the peptide known as Melanotan 2 (MT-II) is the generic term for a new pharmaceutical grade synthetic aphrodisiac research peptide. It has been developed to address Erectile/Sexual Dysfunction or impotence in men, as well as sexual dysfunction in women (sexual arousal disorder). More than 40 per cent of women suffer from female sexual dysfunction'. PT-141 is the only synthetic aphrodisiac. Unlike and other related medications (PDE5s), PT-141
does not act upon the vascular system, but directly through the nervous system (hypothalamus) to increase desire. , Cials and Levitra are not considered aphrodisiacs as they do not have any direct effect on the libido. However, treatment with PDE5 inhibitors and PT-141 are known to have a synergistic effect.
Function
PT-141 is a potential remedy for the treatment of sexual dysfunction; specifically, male erectile dysfunction. Studies have shown that PT-141 does not act on the vascular system like former compounds, but allegedly works by activating melanocortin receptors in the brain, therefore helping increase ones sexual stimulation. PT-141 is a melanocortin based peptide that has shown effectiveness in clinical studies on both male and female rats. Male rats have shown erectile response with doses as low as 1-2 mgs whereas most female rats have shown positive results with higher doses around 2-3 mgs. While the dosage requirements tend to be higher for female rats, the observable results in female rats tend to be stronger.
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