Product Information

CAS.No	30123-17-2
Product name	Tianeptine sodium salt
MF	C21H24ClN2NaO4S
MW	458.93
EINECS	250-059-3

Tianeptine Sodium is a drug used for treating major depressive episodes (mild, moderate, or severe). It has structural similarities to the tricyclic antidepressants, but it has different pharmacological properties. Tianeptine is a selective serotonin reuptake enhancer (SSRE), opposite to the action of SSRIs. One review points to the cancellative effects of tianeptine and fluoxetine coadministration on serotonin reuptake.

Function:
1) Tianeptine Sodium Improves Depressive Symptoms.
2) Tianeptine Sodium Lessens Anxiety, Stress, and PTSD and Symptoms From Stress. 
3) Tianeptine Sodium Benefits Memory and Learning.
4) Tianeptine Sodium is an Anti-inflammatory.
5) Tianeptine Sodium decreases pain.
6) Tianeptine Sodium Helps Treat Irritable bowel Syndrome.
7) Tianeptine Sodium Reduces Asthma.

Application
Tianeptine sodium salt is a salt of Tianeptine. Tianeptine, a tricyclic compound, is a selective facilitator of 5-HT (serotonin; sc-201146) uptake in vitro and in vivo. Additionally, Tianeptine is reported to act as a selective inhibitor of dopamine uptake . Tianeptine does not have a noted effect on monoamine uptake. In a study utilizing purified synaptosomes from rat brain, Tianeptine was reported to enhance serotonin uptake in selective brain regions. Purified synaptosomes were obtained from rats and incubated with tritium-labeled 5-HT and Tianeptine in vitro . The synaptosomes were then analyzed for uptake and release of 5-HT via a liquid scintillation.

Tianeptine is antidepressant. The animal has: the hippocampus pyramidal cells increased spontaneous activity, and accelerating its function was inhibited after recovery; increase in cortical and hippocampal neurons at sites of 5- serotonin reuptake. Tianeptine without following adverse effects: sleep and alertness; cardiovascular system; cholinergic system ( without anticholinergic symptoms ); drug craving.

COA

Items	Specification	Result
Tianeptine Sodium	99%	99.02%
Organoleptic
Appearance	Fine Powder	Conforms
Color	White powder	Conforms
Odor	Characteristic	Conforms
Taste	Characteristic	Conforms
Physical Characteristics
Particle Size	NLT 100% Through 80 mesh	Conforms
Loss on Drying	<=12.0%	Conforms
Ash (Sulphated Ash)	<=0.5%	Conforms
Total Heavy Metals	≤10ppm	Conforms
Microbiological Tests
Total Plate Count	≤10000cfu/g	Conforms
Total Yeast & Mold	≤1000cfu/g	Conforms
E.Coli	Negative	Negative
Salmonella	Negative	Negative
Staphylococcus	Negative	Negative